Nesina | alogliptin
Medication Class: Dipeptidyl peptidase-4 (DPP-4) inhibitor
Similar Drugs: Sitagliptin (Januvia), Saxagliptin (Onglyza), Linagliptin (Tradjenta), Januvia (sitagliptin)
Manufacturer: Takeda Pharmaceutical Company Limited
Approval Date: January 25, 2013
Nesina (alogliptin) Side effects, Cost, Prescribing Information
What is Nesina and how does it work (mechanism of action)
Nesina is an oral prescription medication and it works by inhibiting DPP-4 enzyme. By doing so, it delays the inactivation of incretin hormones GLP-1 and GIP, which regulate insulin and glucagon, lowering blood glucose. DPP-4 inhibitors increase the amount of two proteins (incretin hormones) found in the body, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretin hormones tell the body to release insulin and lower blood glucose. GLP-1 also decreases the production of glucose and slows down the absorption of glucose.
Incretin hormones are removed from the body by an DPP-4. DPP-4 inhibitors like Nesina block this enzyme resulting in GLP-1 and GIP to stay in the body longer and therefore decrease blood glucose levels.
What does Nesina treat
Nesina lowers fasting and post-prandial glucose in adults with type II diabetes. Nesina should not be used in adults with type I diabetes or diabetic ketoacidosis.
How effective is Nesina
What are the side effects of Nesina
What is the dosage of Nesina
Forms and Strength: Nesina comes in dosage strengths of 6.25 mg, 12.5 mg and 25 mg film-coated tablets.
Dosing: The recommended dosage is 25 mg orally once daily with or without food in adults.
Dose adjustments may be necessary for individuals with poor kidney function.
Nesina drug interactions
No significant drug-drug interactions are listed for Nesina.
What is the price of Nesina
Nesina costs about $309.96 for a 30 day supply.
How to obtain prescription cost assistance for Nesina
Pay only $4 a month for up to 12 months with Takeda Diabetes Advantage Savings Card.
Nesina Package Insert and Medication Guide
Red Book. Micromedex 2.0 Online. Date accessed 09/16/2013.
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