Adderall XR (amphetamine salts) side effects, addiction, dosing, efficacy | | RxEconsult

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Adderall XR (amphetamine salts) side effects, addiction, dosing, efficacy Category: ADHD, Autism, Seizures, by - October 28, 2011 | Views: 30153 | Likes: 0 | Comment: 0  

Adderall XR | amphetamine and dextroamphetamine (amphetamine salts)

Medication Class: Central Nervous System Stimulants
Approval date:October 2001

What is Adderall XR and how does it work

Adderall XR is a central nervous system (CNS) stimulant that increases the concentration of neurotransmitters (norepinephrine and dopamine) in the brain. The mechanism of action in ADHD is unknown. Adderall XR is a controlled substance (CII) because it can be abused or lead to addicition.

What does Adderall XR treat

  • Attention deficit hyperactivity disorder (ADHD) in children and adults.

How effective is Adderall XR

  • Adderall XR 10, 20, or 30 mg once daily in the morning were more effective than placebo in a 3 week study of pediatric patients (6-12 years old) with ADHD. Improvement occurred as early as the first week of treatment
  • Adderall XR 20, 40, or 60 mg once daily in the morning for 4 weeks were more effective than placebo in adults with ADHD. The 40 and 60 mg doses were not much more effective than the 20 mg dose.

What are interesting facts about Adderall XR

  • It is an extended release (once daily) formulation of Adderall (immediate release).
  • It is a stimulant but yet it is effective in hyperactive individuals.
  • Adderall XR and Adderall (immediate release) are manufactured by different companies.

How is Adderall XR dosed and administered

Adderall XR is administered without regards to meals. Capsules may be swallowed whole or the entire contents may be sprinkled into applesauce and consumed immediately. Adderall XR should be administered in the morning because it can cause insomnia (difficulty sleeping).

Children (6-12 years old): 10-30 mg daily

Adolescents (13-17 years old): 10-20 mg daily

Adults: 20-60 mg daily

What are the side effects of Adderall XR

Common: Headache, stomach ache, trouble sleeping, weight loss, dry mouth, fast heart beat, decreased appetite, nervousness, mood swings, dizziness.

Serious: Sudden death, stoke, heart attack, high blood pressure, depression, manic episodes, aggressive behavior or hostility, psychosis, seizures, addiction, withdrawal symptoms, growth suppression (longterm use), severe allergic reactions.

Adderall XR drug interactions

  • Monoamine oxidase inhibitors (MAOI) (e.g., tranylcypromine, Zyvox)
  • Antacids
  • Antidepressants
  • Blood pressure reducing medications
  • Lithium

What is the cost of Adderall XR

$7-$12 per tablet

How to obtain prescription assistance for Adderall XR

For prescription assistance for Adderall XR visit Shire patient assistance program.

References:Adderall XRFDA Prescribing Information and Medication Guide

Author: Omudhome Ogbru, PharmD

Related Article:Adderall Shortage | Adderall

This medication summary is for information only and is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider.

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