Farxiga | dapagliflozin
Drug Class: Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitor
Similar Drugs: Invokana (canagliflozin), Jardiance (empagliflozin)
Manufacturer: Bristol-Myers Squibb and AstraZeneca
Approval Date: January 2014
What is Farxiga
Farxiga is a medication that decreases blood glucose (sugar) in people with diabetes by blocking the kidney from reabsorbing glucose and removing excess glucose through the urine. It does this by blocking the sodium-glucose co-transporter-2 (SGLT2) which is a protein in the kidney that is responsible for reabsorbing glucose back into the body. Lowering high blood glucose can help prevent nerve problems, blindness, and kidney damage in people with diabetes. Proper control of blood glucose can also decrease the risk of getting a heart attack or stroke.
What is Farxiga used for
Farxiga is indicated for blood glucose control in patients who have type 2 diabetes. It should be used together with a proper diet and exercise.
How well does Farxiga work
A total of 485 previously untreated subjects with uncontrolled type 2 diabetes and an HbA1c (blood sugar average for the last three months) between 7-10% were studied in a 24-week trial. They were placed in a group either taking Farxiga 5 mg, Farxiga 10 mg, or placebo (a pill containing only sugar).
Farxiga 5 mg group
- 50.8% achieved an HbA1c <7% and a decrease of 28.8 mg/dL in fasting blood glucose
Farxiga 10 mg group
- 44.2% achieved an HbA1c <7% and a decrease of 24.1 mg/dL in fasting blood glucose
- 31.6% achieved an HbA1c <7% and a decrease of 4.1 mg/dL in fasting blood glucose
- Farxiga 5 mg group
A total of 546 subjects with inadequately controlled type 2 diabetes and an HbA1c between 7-10% and already on metformin participated in a 24-week study. They were placed in a group either taking a combination of Farxiga 5 mg with metformin, Farxiga 10 mg with metformin, or placebo with metformin.
Farxiga 5 mg plus metformin
- 37.5% achieved an HbA1c <7% and a decrease of 21.5 mg/dL in fasting blood glucose
Farxiga 10 mg plus metformin
- 40.6% achieved an HbA1c <7% and a decrease of 23.5 mg/dL in fasting blood glucose
Placebo plus metformin
- 25.9% achieved an HbA1c <7% and a decrease of 6.0 mg/dL in fasting blood glucose
- Farxiga 5 mg plus metformin
A total of 182 subjects with type 2 diabetes were evaluated on the change in total body weight (TBW) and were treated with a combination of Farxiga 10 mg with metformin or placebo with metformin.
- After 24 weeks, the Farxiga group had an average weight reduction of -2.96 kg versus -0.88 kg in the placebo group.
After 102 weeks, the Farxiga group had an average weight reduction of -5.43 kg versus -2.12 kg in the placebo group.
How is Farxiga different from other diabetes agents
- Farxiga is a sodium-glucose co-transporter-2 (SGLT2) inhibitor. It is the second drug of this class.
- When taken with a healthy diet, exercise, or other medications that lower blood glucose, Farxiga reduces blood glucose levels even more.
- Unlike the first drug of this class, Invokana (canagliflozin), Farxiga does not increase the level of potassium in the blood (hyperkalemia) and can be taken with or without food.
- There is a risk of bladder cancer when taking Farxiga.
What is the dosage of Farxiga
Farxiga comes in 5 mg and 10 mg tablets. The starting dose of Farxiga is 5 mg once daily in the morning, with or without food. Patients who need additional blood glucose control can be increased to a dose of 10 mg once daily.
What are the side effects of Farxiga
Common: Fungal infections especially in women; common cold symptoms such as runny nose, sore throat, or nasal congestion; urinary tract infections
Serious: Low blood glucose (if taken with another blood glucose lowering agent), kidney problems, increase in cholesterol, low blood pressure, bladder cancer
Farxiga Drug Interactions
There are no known drug interactions. It does not interact with metformin (Glucophage), pioglitazone (Actos), sitagliptin (Januvia), glimepiride (Amaryl), simvastatin (Zocor), or hydrochlorothiazide (Microzide).
What is the price of Farxiga
The price of Farxiga at the local pharmacy for both 5 mg and 10 mg tablets is about $11.57 per tablet and $343.99 for a 30 day supply (30 tablets).
How to obtain prescription cost assistance for Farxiga
Use these resources for cost assistance
Call 1-800-AZandMe (292-6363), for any questions regarding AstraZeneca programs, eligibility requirements, or the application process
Farxiga Prescribing Information (Package Insert, Label)
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