Harvoni (ledipasvir & sofosbuvir) Hep C Treatment: Dosage, Cure Rate, Side Effects, Cost, And Prescribing Information | Kunchok Dolma, PharmD | RxEconsult
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Harvoni (ledipasvir and sofosbuvir), Dosage, Side Effects, Cost, and Prescribing Information for Hepatitis C Category: Hepatitis by - October 27, 2014 | Views: 75244 | Likes: 4 | Comment: 1  

What are the cure rates for Harvoni?

The cure rates for Harvoni were evaluated in 3 clinical studies. All subjects received a single daily tablet of Harvoni (ledipasvir 90 mg and sofosbuvir 400 mg) for either 8, 12 or 24 weeks.

Treatment-naive patients without liver cirrhosis

All subjects received either Harvoni for 8 weeks or Harvoni for 12 weeks. In previously untreated subjects without cirrhosis, 94% of those who received Harvoni for 8 weeks achieved sustain virological response (SVR) and 96% of those who received Harvoni for 12 weeks achieved SVR.

SVR (Cure Rate) For treatment- naive patients with or without cirrhosis

All subjects received either Harvoni for 12 weeks or Harvoni for 24 weeks. In previously untreated subjects with or without cirrhosis, 99% of those who received Harvoni for 12 weeks achieved sustain virological response (SVR) and 96% of those who received Harvoni for 24 weeks achieved SVR. SVR is a measure of the cure rate.

SVR (Cure Rate) for treatment-experienced patients with cirrhosis

All subjects received Harvoni for 12 or 24 weeks. In previously treated subjects with cirrhosis, 94% of those who received Harvoni for 12 weeks achieved sustain virological response (SVR) and 99% of those who received Harvoni for 24 weeks achieved SVR.

Interesting Facts about Harvoni

  • It is the first combination drug approved by the FDA to treat chronic HCV genotype 1.

  • It is the first approved regimen to treat chronic HCV infection that does not require interferon or ribavirin.

  • Harvoni is the third drug approved by the FDA in 2014 for the treatment of chronic HCV infection.

Next: Side Effects, Dosage

Also Read: Zepatier (elbasvir & grazoprevir), Dosage, Side Effects, Cost, Cure Rates, And Prescribing Information For Hepatitis C

 
 


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