Kynamro (mipomersen) Price, Side Effects, Dosing, Prescribing Information

Category: Cholesterol by Jonah-Lynne Padigus, PharmD - January 10, 2014 | Views: 3665 | Likes: 3 | Comment: 0

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Kynamro | mipomersen

Kynamro (mipomersen) for hypercholesterolemiaDrug Class: Cholesterol-Lowering Agent; apolipoprotein B synthesis inhibitor  
Manufacturer: Genzyme
Approval Date: January 2013

What is Kynamro

Kynamro is a cholesterol-lowering medication that prevents an enzyme (protein) called apolipoprotein B100 synthesis from making too much cholesterol in the body. It decreases the “bad” cholesterol from the blood, such as low density lipoprotein (LDL), non-high density lipoprotein (non-HDL), apolipoprotein B (apo B), and total cholesterol (TC).

What is Kynamro used for

Kynamro is prescribed for patients with a rare inherited condition (genetic disorder) called homozygous familial hypercholesterolemia (HoFH) which causes high cholesterol. It should be used together with a low-fat diet and other medications that help lower cholesterol.

How well does Kynamro work

  • A 26-week study compared 34 subjects on Kynamro in addition to their usual cholesterol-lowering medications against 17 subjects who were only taking their cholesterol-lowering medications. Subjects in the Kynamro group received 200 mg weekly injections under the skin.
  • The Kynamro group had an average LDL decrease of 25% compared to a 3% decrease in subjects taking only their lipid-lowering agents.

How is Kynamro different from other lipid-lowering agents

  • Kynamro works by blocking apolipoprotein B100 (apolipoprotein B synthesis inhibitor ).
  • It is an injection.
  • It is injected once weekly.

What is the dosage of Kynamro

Kynamro is supplied as a single-use vial containing 1 mL of a 200 mg/mL solution and a single-use pre-filled syringe containing 1 mL of a 200 mg/mL solution. The dose is 200 mg injected under the skin once weekly.

What are the side effects of Kynamro

Common: Pain, redness, itching, or swelling at the injection site; flu-like symptoms such as fever, chills, or muscle pain; nausea; headache; and increases in liver enzymes (when the liver gets damaged, enzymes are released)

Serious: Increase in liver fat (hepatic steatosis) which may lead to advanced liver disease. 

Note: Due to the risk of liver damage, Kynamro is only available through the restricted program called KYNAMRO REMS.

Kynamro Drug Interactions

There are no known drug interactions. It does not interact with warfarin (Coumadin), simvastatin (Zocor), or ezetimibe (Zetia).

What is the price of Kynamro

According to the manufacturer, Kynamro costs around $176,000 each year, which is about $3,667 a week. According to Red Book, 1 vial of Kynamro has an Average Whole Sale Price (AWP) of $5,759.65.

How to obtain prescription cost assistance for Kynamro

Use these resources for cost assistance

References

Kynamro Prescribing Information (Package Insert, Label)

 

The material on this site is for information only and is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider.
 

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