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Kynamro | mipomersen
What is Kynamro
Kynamro is a cholesterol-lowering medication that prevents an enzyme (protein) called apolipoprotein B100 synthesis from making too much cholesterol in the body. It decreases the “bad” cholesterol from the blood, such as low density lipoprotein (LDL), non-high density lipoprotein (non-HDL), apolipoprotein B (apo B), and total cholesterol (TC).
What is Kynamro used for
Kynamro is prescribed for patients with a rare inherited condition (genetic disorder) called homozygous familial hypercholesterolemia (HoFH) which causes high cholesterol. It should be used together with a low-fat diet and other medications that help lower cholesterol.
How well does Kynamro work
How is Kynamro different from other lipid-lowering agents
What is the dosage of Kynamro
Kynamro is supplied as a single-use vial containing 1 mL of a 200 mg/mL solution and a single-use pre-filled syringe containing 1 mL of a 200 mg/mL solution. The dose is 200 mg injected under the skin once weekly.
What are the side effects of Kynamro
Common: Pain, redness, itching, or swelling at the injection site; flu-like symptoms such as fever, chills, or muscle pain; nausea; headache; and increases in liver enzymes (when the liver gets damaged, enzymes are released)
Serious: Increase in liver fat (hepatic steatosis) which may lead to advanced liver disease.
Note: Due to the risk of liver damage, Kynamro is only available through the restricted program called KYNAMRO REMS.
Kynamro Drug Interactions
There are no known drug interactions. It does not interact with warfarin (Coumadin), simvastatin (Zocor), or ezetimibe (Zetia).
What is the price of Kynamro
According to the manufacturer, Kynamro costs around $176,000 each year, which is about $3,667 a week. According to Red Book, 1 vial of Kynamro has an Average Whole Sale Price (AWP) of $5,759.65.
How to obtain prescription cost assistance for Kynamro
Use these resources for cost assistance
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