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New Drugs For HIV Treatment Category: Viral Infections by - September 5, 2017 | Views: 8967 | Likes: 0 | Comment: 0  

Odefsey (emtricitabine, tenofovir alafenamide, rilpivirine)

It is a three-drug combination of emtricitabine and tenofovir alafenamide (both HIV nucleoside analog reverse transcriptase inhibitors), and rilpivirine (a non-nucleoside reverse transcriptase inhibitor). Emtricitabine, tenofovir, and rilpivirine block the action of reverse transcriptase, an enzyme that HIV virus uses to produce viral DNA and for viral replication. Odefsey was approved by the FDA in March, 2016.

Side Effects of Odefsey

  • Lactic acidosis and severe liver enlargement with steatosis
  • Severe and sudden worsening of hepatitis B infection
  • Severe infections with inflammation
  • Rash, fever, blisters
  • Depressive disorders – depressed mood, negative thoughts, trouble sleeping
  • Liver damage
  • Kidney dysfunction
  • Bone loss

Some Facts About Odefsey

  • One tablet should be taken once daily by mouth.
  • It requires good kidney function (creatinine clearance of at least 30 ml/min)
  • Patients need to be tested for hepatitis B virus infection.
  • It can be used as a single agent for antiretroviral therapy.
  • It should be taken at least 2 hours before or after taking any antacids.
  • Changes in body fat can occur, especially in upper back, neck, breast, and trunk.
  • Odefsey is a tablet that contains 200 mg of emtricitabine, 25 mg of rilpivirine, and 25 mg of tenofovir alafenamide.

The average wholesale price of each tablet is $100.31 and 30 tablets cost $3009.29.

Descovy (emtricitabine and tenofovir alafenamide)

It is a two-drug combination of emtricitabine and tenofovir alafenamide which are HIV nucleoside analog reverse transcriptase inhibitors. Emtricitabine and tenofovir alafenamide are also components of Odefsey and Genvoya (discussed previously). Descovy was approved by the FDA in April, 2016.

Side Effects of Descovy

  • Lactic acidosis and severe liver enlargement with steatosis   
  • Severe and sudden worsening of hepatitis B infection
  • Severe infections with inflammation
  • Kidney dysfunction
  • Bone loss
  • Nausea
  • High cholesterol

Some Facts About Descovy

  • One tablet should be taken once daily by mouth.
  • It requires good kidney function (creatinine clearance of at least 30 ml/min).
  • Patients need to be tested for hepatitis B virus infection.
  • Changes in body fat can occur especially in upper back, neck, breast, and trunk.
  • Descovy is a tablet that contains 200 mg of emtricitabine and 25 mg of tenofovir alafenamide.

The average wholesale price is $62.71 per tablet and 30 tablets cost $1881.14.

References

Clay PG, Nag S, Graham CM, Narayanan S. Meta-Analysis of Studies Comparing Single and Multi-Tablet Fixed Dose Combination HIV Treatment Regimens. Cobo. RT, ed. Medicine. 2015;94(42) 

Bartlett JA, DeMasi R, Quinn J, Moxham C, Rousseau F. Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults. AIDS. 2001;15:1369–77.  

Yang H, Nkeze J, Zhao RY. Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapyCell & Bioscience. 2012;2:32. doi:10.1186/2045-3701-2-32. 

HIV/AIDS. CDC, Centers of Disease Control and Prevention. May 30, 2017

Selecting an Initial ART Regimen-AIDS Institute Clinical Guidelines. HIV Clinical Resource. April, 2017 

Antiretroviral drugs used in the treatment of HIV infection. FDA. August, 2016.

Evotaz, Prezcobix, Genvoya, Odefsey, Descovy. FDA Prescribing Information (Package Insertss, Labels)

Evotaz, Prezcobix, Genvoya, Odefsey, Descovy. Up To Date. 2017

Evotaz, Prezcobix, Genvoya, Odefsey, Descovy. RED BOOK online

 



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