Interesting facts about Onzetra Xsail
First sumatriptan powder formulation for nasal delivery.
First breath-powered intranasal delivery system. The amount of drug delivered to the nose is dependent on the patient's exhaling capacity (more information in dosage and administration section).
In one study, the average delivered dose for each nostril ranged from 7.5 to 8.1 mg per treatment (each capsule contains 11 mg).
The therapeutic concentration of sumatriptan is 18-60 ng/mL. The maximum concentration following Onzetra Xsail is 21 ng/mL.
Onzetra Xsail shares similar pharmacokinetics with the available sumatriptan nasal spray (Imitrex Nasal Spray).
The bioavailability for Onzetra Xsail is 19%, Imitrex Nasal Spray is 14%, and for oral sumatriptan is 15%.
What are side effects of Onzetra Xsail?
The most common side effects of Onzetra Xsail include:
Possible serious side effects of Onzetra Xsail include:
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