Revatio | Sildenafil

Medication Class: Phosphodiesterase-5 inhibitor (PDE-5 inhibitor)
Manufacturer: Pfizer
Approval Date: March, 1998

What is Revatio and how does it work

Revatio reduces pressure in the pulmonary artery in patients with pulmonary arterial hypertension by inhibiting the enzyme phosphodiesterase-5 (PDE-5).

What is Revatio used for

• Pulmonary arterial hypertension (PAH)

How effective is Revatio

• Revatio increased 6-minute walking distance by 40-50 meters compared to placebo after 12 weeks of treatment.
• Patients taking Revatio were were 3 times less likely to to experience a clinically worsening event.
• Patients taking Revatio experienced a significant delay in clinical worsening.

What are interesting facts about Revatio

• First approved phosphodiesterase-5 inhibitor
• Also used for treating erectile dysfunction (Viagra)
• Delays worsening of clinical events and fewer patients experience clinical events

​What is Revatio dosage and administration

20 mg orally 3 times daily or 10 mg by injection 3 times daily

What are Revatio side effects 

Common: Headache, flushing, stomach upset, shortness of breath, insomnia, nosebleed

Serious: Low blood pressure, heart attack, stroke, vision hearing loss, seizures, sudden death, priapism, Non Arteritic Ischemic Optic Neuropathy (NAION)

Revatio drug interactions

• Other PDE-5 inhibitors (Viagra, Cialis, Levitra)
• Imdur (Isosorbide mononitrate)
• Isordil (Isosorbide dinitrate)
• Nitro-Dur, Transderm-Nitro (nitroglycerine)
• Sporanox (itraconazole)
• Erythromycin
• Nizoral (ketoconazole)
• Tagamet (cimetidine)
• HIV protease inhibitors (e.g., Norvir)
• Victrelis (boceprivir)
• Incivek (telaprivir)
• Rifampin

What is the price of Revatio

Revatio 20 mg tablets 3 times daily cost about $33.75 or more per day.

How to obtain prescription assistance for Revatio

For Revatio prescription assistance program visit the Pfizer prescription program.

References: Revatio FDA Prescribing Information (PI)

The material on this site is for information only and is not a substitute for medical advice, dianosis or treatment provided by a qualified healthcare provider.

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