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Revatio (sildenafil) Uses, Side Effects, Dosage Category: Pulmonary Hypertension by - September 28, 2011 | Views: 5994 | Likes: 0 | Comment: 0  

Revatio | Sildenafil

Medication Class: Phosphodiesterase-5 inhibitor (PDE-5 inhibitor)
Manufacturer: Pfizer
Approval Date: March, 1998

What is Revatio and how does it work

Revatio reduces pressure in the pulmonary artery in patients with pulmonary arterial hypertension by inhibiting the enzyme phosphodiesterase-5 (PDE-5).

What is Revatio used for

  • Pulmonary arterial hypertension (PAH)

How effective is Revatio

  • Revatio increased 6-minute walking distance by 40-50 meters compared to placebo after 12 weeks of treatment.
  • Patients taking Revatio were were 3 times less likely to to experience a clinically worsening event.
  • Patients taking Revatio experienced a significant delay in clinical worsening.

What are interesting facts about Revatio

  • First approved phosphodiesterase-5 inhibitor
  • Also used for treating erectile dysfunction (Viagra)
  • Delays worsening of clinical events and fewer patients experience clinical events

​What is Revatio dosage and administration

20 mg orally 3 times daily or 10 mg by injection 3 times daily

What are Revatio side effects 

Common: Headache, flushing, stomach upset, shortness of breath, insomnia, nosebleed

Serious: Low blood pressure, heart attack, stroke, vision hearing loss, seizures, sudden death, priapism, Non Arteritic Ischemic Optic Neuropathy (NAION)

Revatio drug interactions

  • Other PDE-5 inhibitors (Viagra, Cialis, Levitra)
  • Imdur (Isosorbide mononitrate)
  • Isordil (Isosorbide dinitrate)
  • Nitro-Dur, Transderm-Nitro (nitroglycerine)
  • Sporanox (itraconazole)
  • Erythromycin
  • Nizoral (ketoconazole)
  • Tagamet (cimetidine)
  • HIV protease inhibitors (e.g., Norvir)
  • Victrelis (boceprivir)
  • Incivek (telaprivir)
  • Rifampin

What is the price of Revatio

Revatio 20 mg tablets 3 times daily cost about $33.75 or more per day.

How to obtain prescription assistance for Revatio

For Revatio prescription assistance program visit the Pfizer prescription program.

References: Revatio FDA Prescribing Information (PI)

 

The material on this site is for information only and is not a substitute for medical advice, dianosis or treatment provided by a qualified healthcare provider.

 

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