Reversal Of Pradaxa (dabigatrae etexilate mesylate) With An Antidote And Other Methods | Kent Pham, PharmD | RxEconsult
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Reversing The Effect Of Pradaxa (dabigatran) On Bleeding Category: Anticoagulation (clot prevention) by - February 15, 2013 | Views: 44501 | Likes: 2 | Comment: 3  

Activated Charcoal

In the event of acute ingestion of Pradaxa (< 2 hours), administering activated charcoal will help absorb Pradaxa. Administering fluids, blood, and monitoring the patient as dictated by the situation or hospital protocol for acute bleeds is recommended.

Hemodialysis

Hemodialysis can remove 60% of dabigatran. Dabigatran is eliminated through the kidneys. The half-life increases by 24 hours when dabigatran is given in patients with impaired renal function (creatinine clearance < 30 ml/min). Natural elimination is through the urine.

Antifibrinolytic agent

Antifibrinolytic agents may be considered for moderate to severe bleeding. Intravenous tranexamic acid along with fluid replacement and blood product transfusion may be used. Prothrombinex-VF can be used to restore normal clotting factor IX, factor II, factor X and low level of factor VII.

Next: Clotting Factors, Pradaxa Antidote

 


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