“Sorry honey, I’m not in the mood.” Sound familiar? It’s a common phrase muttered by exhausted wives, girlfriends, and life partners. But are they really that tired? Or is it something else? Females may have a condition called hypoactive sexual desire disorder (HSDD) in which females have a low libido (do not have interest in sex), causing distress or difficulty in the sexual relationship. The low libido is not caused by medications, stress within the relationship, or a co-existing medical or psychiatric condition. HSDD affects up to 33% of female patients in the United States, making it more prevalent than the other two female sexual disorders: anorgasmia and dyspareunia. Fortunately, there is a treatment option. In August 2015, the FDA approved Addyi, the first libido pill indicated for HSDD in pre-menopausal women.
How does Addyi work?
Addyi (flibanserin) works centrally in the brain, stimulating serotonin 1A receptors and blocking serotonin 2A receptors. The exact mechanism of how serotonin affects sexual desire is unknown. Addyi does not work in women the same way that Viagra works for men and should not be viewed as Viagra for women.