Brand Name: Tanzeum
Generic Name: albiglutide
Drug Class: Glucagon-like peptide-1 (GLP-1) receptor agonist
Similar Drugs: Victoza (liraglutide) Byetta (exenatide) Bydureon (exenatide extended release)
FDA Approval Date: April 15, 2014
What is Tanzeum and its mechanism of action?
Tanzeum is a new injectable diabetes drug approved by FDA in April 2014 for use in adults with type 2 diabetes mellitus. Tanzeum belongs to a group of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists because they resemble and mimic the action of human GLP-1 hormone (incretin hormone). They are also known as incretin mimetics. It is an injectable drug that reduces blood glucose by increasing insulin production by the pancreas, slows the absorption of glucose from the gut, reduces the activity of glucagon (a hormone that increases the release of glucose from the liver), and reduces appetite.
What does Tanzeum treat?
Tanzeum is combined with diet and exercise to improve glucose control in adults with type 2 diabetes mellitus.
Who should not use Tanzeum?
How effective is Tanzeum?
Monotherapy: In a 52-week long trial, 296 patients were randomly placed on Tanzeum 30 mg treatment or placebo. By week 52 there was a significant decrease in HbA1C levels from the baseline in patients on 30 mg (-0.7%) or 50 mg (-0.9%) of Tanzeum compared to patients on placebo (+0.2%). There was no significant change in the average body weight from the baseline reported in this study.
Combination Therapy: During a 104-week long trial, 999 patients with type 2 diabetes mellitus inadequately controlled on metformin therapy were randomly given Tanzeum 30 mg or placebo, sitagliptin 100 mg daily, or glimepiride 2 mg daily. By week 104 there was a significant decrease in HbA1C levels from the baseline in patients on Tanzeum 30 mg plus metformin (-0.6%) compared to placebo plus metformin (+0.3%), sitagliptin plus metformin (-0.3%), or glimepiride plus metformin (-0.4%). There was also a significant change in average body weight from the baseline between Tanzeum (90 kg) and glimepiride (92 kg).
Interesting facts about Tanzeum
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