Toujeo (insulin glargine) Solostar Pen Dosing, Side Effects, Cost, And Prescribing Information For Diabetes Treatment | Jessica Pourtaverdi, PharmD | RxEconsult

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Toujeo (insulin glargine) Dosing, Side Effects, Cost, And Prescribing Information For Diabetes Treatment Category: Diabetes by - April 6, 2016 | Views: 63512 | Likes: 0 | Comment: 0  

What are side effects of Toujeo?

Side effects of Toujeo are similar to side effects of other insulins and include:

  • Severe hypoglycemia is the most common side effect observed in diabetes patients. Symptoms of hypoglycemia include blurry vision, rapid heartbeat, pale skin, headache, fatigue, tremor, and hunger.
  • Allergic reactions such as redness, rash, itching, inflammation, pain, and urticaria.
  • Weight gain
  • Low levels of potassium in your blood.
  • Lipodystrophy, which is an abnormal deposit of fat tissue that happens at the site of injection from long-term use of insulin.
  • Taking Toujeo with thiazolidinediones (TZDs) may cause heart failure.

What is the dosing of Toujeo and how is it administered?

Toujeo is available as a SoloStar disposable prefilled pen. The solution in the 1.5 mL pen contains 300 units/mL of insulin glargine (450 units/1.5 mL). Toujeo should not be administered intravenously, intramuscularly, or via insulin pump due to severe hypoglycemia. It can only be administered subcutaneously into the abdomen, thigh, or deltoid. Patients should rotate injections sites to reduce the risk of lipodystrophy. Only use Toujeo if the solution is clear and colorless.

Dosing is based on the patient's blood glucose control goals and the dose is adjusted according to response. Doses should be titrated every 3 to 4 days to minimize the risk of hypoglycemia.

The maximum glucose effect of a dose of Toujeo may not occur for five days. Therefore, the first Toujeo dose may not adequately cover metabolic needs in the first 24 hours of use.  

Type 1 Diabetes:

The recommended Toujeo dose for insulin naive patients is one-third to one-half of the total daily insulin dose once daily.

Type 2 Diabetes:

The recommended starting Toujeo dose for insulin naive patients is 0.2 units/kg of body weight once daily.

Converting From Lantus to Toujeo:

The starting dose of Toujeo can be the same as Lantus, however, expect a higher daily dose of Toujeo to maintain the same level of glycemic control.

Converting From NPH to Toujeo:

When switching from twice-daily NPH insulin to Toujeo, the starting dose of Toujeo should be 80% of the total daily NPH dose.

Next: Storage, Drug Interactions 


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