What is Victrelis (boceprevir), Side Effects, Dosing, Price, and Package insert (PI) | Omudhome Ogbru, PharmD | RxEconsult
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Victrelis (boceprevir) Side Effects, Dosing, Price, Package Insert Category: Hepatitis by - September 20, 2011 | Views: 13763 | Likes: 0 | Comment: 0  
Victrelis| boceprevir Victrelis (boceprevir) for hep C
 
Drug Class: protease inhibitor
Similar Drugs: IncivekSovaldiOlysio
Manufacturer: Merck
Approval Date: May 2011
 
What is Victrelis
Victrelis is a protease inhibitor used for treating chronic hepatitis C infections. Victrelis reduces the activity of hepatitis C virus protease enzymes which leads to the formation of defective viruses that are unable to multiply in the liver. As a result the hepatitis C viral load decreases.
 
What is Victrelis used for
Victrelis is used for treatment of chronic hepatitis C infection in adults who are receiving treatment for the first time or have failed interferon and ribavirin therapy. It must be combined with peginterferon alfa and ribavirin.
 
How well does Victrelis work
  • In previously untreated subjects, hepatitis C virus levels were undetectable in 66% of Victrelis treated subjects versus 38% of subjects that only received peginterferon alfa and ribavirin.
  • In subjects who failed previous therapy, virus levels were undetectable in 59-66% of Victrelis treated subjects versus 23% of subjects that only received peginterferon alfa and ribavirin.
How is Victrelis different from peginterferon alfa and ribavarin
  • Victrelis is a hepatitis C virus protease inhibitor.
  • It reduces the hepatitis C virus to undetectable levels.
What is the dosage of Victrelis 
Supplied as Victrelis 200 mg capsules.
Dosing is 800 mg administered orally 3 times daily (every 7-9 hours) with a meal or snack.
It is administered in combination with peginterferon alfa and ribavirin.
 
What are the side effects of Victrelis
Common: Weakness, anemia, nausea, headache, and abnormal taste sensation.
Serious: Reduced number of platelets and white blood cells
 
Victrelis Drug interactions
Victrelis interacts with several drugs. Here are some of the drugs it interacts with.
  • Triazolam (Halcion)
  • midazolam (Versed)
  • stavudine (Zerit)
  • clarithromycin (Biaxin)
  • ketoconazole
  • itraconazole (Sporanox)
  • voriconazole (Vfend)
  • sildenafil (Viagra, Revatio)
  • tadalafil (Adcirca, Cialis)
  • vardenafil (Levitra)
  • lovastatin (Mevacor)
  • simvastatin (Zocor) and atorvastatin (Lipitor)
  • rifampin (Rifadin), rifabutin (Mycobutin)
  • St. John's Wort
  • efavirenz (Sustiva).
What is the price of Victrelis 
$179.99 for 12 capsules which is the dose for one day. The cost of Victrelis for 30 days without insurance is $5,399.70
 
 
The material on this site is for information only and is not a substitute for medical advice, diagnosis or treatment provided by a qualified healthcare provider.
 
 

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