What is Zocor (simvastatin) Side Effects, Prescribing Information, Dosage, and Indications | Omudhome Ogbru, PharmD | RxEconsult
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What is Zocor (simvastatin) Side Effects, Prescribing Information, Dosage, and Indications Category: Cholesterol by - September 18, 2011 | Views: 12702 | Likes: 0 | Comment: 0  

Zocor| simvastatin Zocor (simvastatin) for high cholesterol

Medication Class: HMG-CoA reductase inhibitor
Manufacturer: Merck
Approval date: December, 1991

What is Zocor and how does it work

Zocor is a cholesterol lowering medication that works by inhibiting the enzyme HMG-CoA reductase which is needed for the cholesterol production in the liver. Zocor is also classified as an HMG-CoA reductase inhibitor or “statin”.

What is Zocor used for (indications)

  • Reducing total cholesterol level, LDL cholesterol level, and triglycerides
  • Increasing HDL cholesterol
  • Reducing the risk of death from coronary heart disease, reducing nonfatal heart attack and stroke, and reducing the need for coronary and non-coronary revascularization procedures in patients with diabetes, heart disease, history of stroke, or peripheral vascular disease.

How effective is Zocor

  • Reduce LDL cholesterol by 26-47%
  • Reduce triglycerides by 12-33%
  • Increase HDL (good cholesterol) by 10-16%
  • Reduces the risk of death from coronary heart disease, reducing nonfatal heart attack and stroke, and reducing the need for coronary and non-coronary revascularization procedures.

What are interesting facts about Zocor

  • Reduces the risk of death, heart attack, and stroke in patients at risk
  • Interacts with several drugs
  • Reduces LDL, triglycerides, and increases HDL
  • A generic version is available

What is the Dosage for Zocor 

  • Supplied as Zocor 5, 10, 20, 40, 80 mg tablets
  • 5-40 mg/day given by mouth preferably in the evening
  • 80 mg dose is only for those already taking this dose for 12 months or more without developing muscle toxicity

What are the side effects of Zocor

Common: Nausea, vomiting, diarrhea, abdominal pain, headache, muscle pain, and abnormal liver tests.

Statins, including Zocor have been associated with memory loss, increased blood glucose, and diabetes.

Serious: Liver damage, rhabdomyolysis, kidney failure, pancreatitis

Zocor drug interactions

  • Large quantities of grape fruit juice (>1 quart daily)
  • erythromycin (E-Mycin)
  • Clarithromycin (Biaxin), telithromycin (Ketek)
  • ketoconazole (Nizoral), itraconazole (Sporanox)
  • Posaconazole (Noxafil)
  • HIV protease inhibitors (Crixivan, Norvir)
  • Danazol (Danocrine)
  • Cyclosporine (Sandimmune)
  • Amiodarone (Cordarone)
  • Ranolazine (Ranexa)
  • Verapamil (Calan)
  • Diltiazem (Cardizem)
  • Amlodipine (Norvasc)
  • Niacin (Niaspan)
  • Gemfibrozil (Lopid), and fenofibrate (Tricor)
  • Warfarin (Coumadin)
  • Cholestyramine

How to obtain prescription assistance for Zocor

For prescription assistance for Zocor visit Merck Patient Assistance Program.

References: Zocor FDA Prescribing Information

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The material on this site is for information only and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.

 


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