What is Zoloft (sertraline), Side Effects, Dosage, Withdrawal Symptoms | Omudhome Ogbru, PharmD | RxEconsult

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Zoloft (sertraline) dosage, side effects, efficacy Category: Depression, Compulsion, Anxiety by - September 16, 2011 | Views: 9357 | Likes: 0 | Comment: 0  

Zoloft | sertraline

Medication Class: Selective Serotonin Inhibitor
Manufacturer: Pfizer
Approval Date: December, 1991

What is Zoloft and how does it work

Zoloft is an antidepressant that works by increasing the levels of neurotransmitters (serotonin) in the brain. Therefore, it is classified as a selective serotonin inhibitor (SSRI).

What is Zoloft used for

  • Major Depression in adults
  • Obsessive compulsive disorder (OCD) (Adult or children)
  • Panic disorder
  • Posttraumatic stress disorder (PTSD)
  • Premenstrual dysphoric disorder (PMDD)
  • Social anxiety disorder

How effective is Zoloft

  • Antidepressant effect is maintained for 44 weeks after 8 weeks of initial of treatment.
  • Effect on symptoms of PTSD is maintained for 28 weeks after 24 weeks of initial treatment.
  • Effect on symptoms of social anxiety disorder is maintained for 24 weeks following 20 weeks of treatment.

What are interesting facts about Zoloft

  • It is a selective serotonin inhibitor (SSRI)
  • Administered once daily
  • It is used for treating several conditions

What is the dosage of Zoloft and how is it administered

Zoloft is administered once daily by mouth in the morning or evening.

  • Depression and OCD—50-200 mg daily
  • Panic disorder, PTSD, Social anxiety disorder— 25-200 mg daily
  • PMDD—50-150 mg daily
  • OCD (children)—25-200 mg daily

What are the side effects of Zoloft

Common: Dizziness, dry mouth, fatigue, sleepiness, diarrhea, nausea, vomiting, headache, insomnia, ejaculation failure, agitation, weight loss, reduced libido.

Serious: Suicide, manic episodes, seizures, serotonin syndrome, neuroleptic malignant syndrome, abnormal bleeding, low sodium, withdrawal symptoms (anxiety, tiredness, dizziness, headache, difficulty sleeping, confusion)

Zoloft drug interactions

  • Monoamine oxidase inhibitors (MAOI) (e.g., phenelzine)
  • Linezolid (Zyvox)
  • St. John's Wort
  • warfarin
  • Nonsteroidal antiinflammatory drugs (e.g., Motrin, Aleve)
  • Sumatriptan and similar medications
  • Cimetidine
  • Valium (diazepam)
  • Pimozide (Orap)

What is the cost of Zoloft

$3.27-$11.19 per tablet for brand name.

How to obtain prescription assistance for Zoloft

For prescription assistance for Zoloft visit Pfizer Prescription Program.

References: Zoloft FDA Prescribing Information and Medication Guide


This medication summary is for information only and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.




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