List of New Hepatitis C (Hep C) Drugs 

Mavyret (glecaprevir and pibrentasvir); Manufactured by AbbVie and FDA approved in 2017.

Epclusa (sofosbuvir and velpatasvir); Manufactured by Gilead and FDA approved in 2016

Zepatier (elbasvir and grazoprevir); Manufactured by Merck and FDA approved in 2016

Daklinza (daclatasvir); Manufactured by Bristol-Myers Squibb and FDA approved in 2015.

Technivie (ombitasvir, paritaprevir, and ritonavir); Manufactured by AbbVie and FDA approved in 2015.

Harvoni (ledipasvir and sofosbuvir); Manufactured by Gilead and FDA approved in 2015

Viekira Pak (ombitasvir, paritaprevir, and ritonavir tablets; dasabuvir tablets); Manufactured by AbbVie and FDA approved in 2014.

Sovaldi (sofosbuvir); Manufactured by Gilead and FDA approved in 2014

Olysio (simeprevir); Manufactured by Janssen and FDA approved in 2013

Mechanisms of Action

These newer hepatitis c drugs work through inhibition of HCV NS3/4A protease or HCV NS5A/NS5B enzymes and some may be combined with a CYP3A4 inhibitor. HCV NS3/4A protease is an enzyme important for HCV replication and reproduction.

HCV NS5A and NS5B enzymes play a key role in HCV RNA replication and viral assembly. Replication is the process in which the virus uses the host’s cells mechanism to create more virus RNA. Viral assembly is putting that RNA into an actual virus structure which allows HCV to spread.

Some of these drugs may be combined with a CYP3A4 inhibitor, an enzyme involved in the metabolism of potentially toxic compounds, including drugs. Medications that inhibit CYP3A4 can increase the effects of medications that are broken down by these enzymes.

Hep C Drugs That Contain HCV NS3/4A Protease inhibitor

• Mavyret
• Zepatier
• Technivie
• Viekira Pak
• Olysio

Hep C Drugs That Contain HCV NS5A protein inhibitor

• Mavyret
• Epclusa
• Zepatier
• Daklinza
• Technivie
• Harvoni
• Viekira Pak

Hep C Drugs That Contain HCV NS5B RNA Dependent RNA Polymerase Inhibitor

• Epclusa
• Harvoni
• Viekira Pak
• Sovaldi

HCV Genotypes Treated By Each Medication

Currently, there are six genotypes of HCV. HCV medications are effective against specific genotypes. Genotype 1 is the most prevalent in the US.

There are two drugs that currently treat all six HCV genotypes.

• Mavyret
• Epclusa

Eight of the nine drugs are FDA approved for treatment of Genotype 1, which is the most prevalent in the US. These drugs include:

• Mavyret
• Epclusa
• Zepatier
• Daklinza
• Harvoni
• Viekira Pak
• Sovaldi
• Olysio

• Mavyret
• Epclusa
• Sovaldi

Four of the nine drugs are FDA approved to treat Genotype 3. These drugs include:

• Mavyret
• Epclusa
• Daklinza
• Sovaldi

Seven of the nine drugs are FDA approved to treat Genotype 4. These drugs include:

• Mavyret
• Epclusa
• Zepatier
• Technivie (only approved for treating genotype 4)
• Harvoni
• Sovaldi
• Olysio

Three of the nine drugs are FDA approved to treat Genotype 5. These drugs include:

• Mavyret
• Epclusa
• Harvoni

Three of the nine drugs are FDA approved for treatment of Genotype 6. These drugs include:

• Mavyret
• Epclusa
• Harvoni

Next: Cure Rates, Length of Treatment, Use with ribavirin, Cost,