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The Effects Of THC And CBD From Marijuana Category: Pharmacotherapy by - May 4, 2016 | Views: 28666 | Likes: 0 | Comment: 0  

CBD Effects & Potential Applications 

Many of CBD’s effects on the user are the exact opposites of THC. For instance, instead of increasing fatigue, CBD actually promotes wakefulness among its users. Not only does CBD fail to produce a psychoactive reaction in its users it may have antipsychotic effects. Instead of creating anxiety, CBD decreases anxiety and paranoia in animal models. Studies also show that it can counteract the negative psychoactive effects of THC. For these reasons, CBD may be more useful for medical applications. It’s anti-inflammatory, antioxidant, and neuroprotective effects may be useful in treating MS, childhood epilepsy and similar conditions. Continued research suggests that CBD could also protect nerves from damage caused by strokes and other conditions. 

Further medical research is important in providing more insight into the effects of these two powerful and seemingly opposite cannabinoids, especially since laboratory studies and small clinical studies suggest medical uses for THC and CBD. 

References And Resources

Celia J. A. Morgan, Gráinne Schafer, Tom P. Freeman, H. Valerie Curran. Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study. The British Journal of Psychiatry Oct 2010, 197 (4) 285-290

Curran HV, Brignell C, Fletcher S, Middleton P, Henry J. Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology (Berl) 2002; 164: 61– 70.

Bhattacharyya S, Crippa J, Allen P, et al. Induction of Psychosis byΔ9-Tetrahydrocannabinol Reflects Modulation of Prefrontal and Striatal Function During Attentional Salience Processing. Arch Gen Psychiatry. 2012;69(1):27-36.

Nicholson AN1, Turner C, Stone BM, Robson PJ.

Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004 Jun;24(3):305-13.

Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimaraes FS. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res 2006; 39: 421– 9.

Guimares FS, Chiaretti TM, Graeff FG. Antianxiety effects of cannabidiol in the elevated plus-maze. Psychopharmacology 1990; 100: 558– 9.

Morgan CJA, Curran HV. Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. Br J Psychiatry2008 ;192: 306– 7. 

Hermann D, Sartorius A, Welzel H, Walter S, Skopp G, Ende G, et al. Dorsolateral prefrontal cortex N-acetylaspartate/total creatine (NAA/tCr) loss in male recreational cannabis users. Biol Psychiatry2007 ;61: 1281– 9.

Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel

Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells. PLoS One. 2013; 8(4): e61462. Published online 2013 April 24.

Marijuana and Cancer,

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